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Monday, May 11, 2020 | History

4 edition of Group sequential methods with applications to clinical trials found in the catalog.

Group sequential methods with applications to clinical trials

Christopher Jennison

Group sequential methods with applications to clinical trials

by Christopher Jennison

  • 353 Want to read
  • 18 Currently reading

Published by Chapman & Hall/CRC in Boca Raton .
Written in English

    Subjects:
  • Clinical trials -- Statistical methods.,
  • Decision Theory.,
  • Statistics -- methods.,
  • Clinical Trials -- methods.,
  • Models, Statistical.

  • Edition Notes

    Includes bibliographical references (p. [363]-386) and index.

    StatementChristopher Jennison and Bruce W. Turnbull..
    ContributionsTurnbull, Bruce W.
    Classifications
    LC ClassificationsR853.C55 J46 2000
    The Physical Object
    Paginationxviii, 390 p. :
    Number of Pages390
    ID Numbers
    Open LibraryOL21116283M
    ISBN 100849303168

    •Group sequential designs •Blinded sample size re-estimation Opportunities for Adaptive Methods 4. Opportunities yes, but Potential for operational bias: • premature unblinding of interim results –Primary – Clinical response, File Size: 1MB. Group Sequential Design and Analysis A group sequential design provides detailed specifications for a group sequential trial. In addition to the usual specifications, it provides the total number of stages (the number of interim stages plus a final stage) and a stopping criterion to either reject or accept the null hypothesis at each interim stage.

      About For Books Group Sequential Methods with Applications to Clinical Trials (Chapman Hall/CRC. MaxineVance. Follow. 9 months ago PDF Download Group Sequential Methods with Applications to Clinical Trials Chapman HallCRC Download Full Ebook. Choaib15omran.   Sequential clinical trials in practice. Increasingly, sequential procedures are being implemented in modern clinical trials. Peace presents case studies of several applications, some of which have formed part of New Drug Applications (NDAs) that have been approved by the Food and Drug Administration (FDA). Additional examples can be found in Cited by:

    Adaptive design methods in clinical research and development of on-going clinical trials. In addition, this book is intended to give a commonly used adaptive group sequential design methods in clinical trials. Blinded procedures for sample size re-estimation are given inFile Size: 2MB. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application.


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Group sequential methods with applications to clinical trials by Christopher Jennison Download PDF EPUB FB2

Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical by:   Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis.

These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its Edition: 1st. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses.

It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials.

Download Citation | On Feb 1,KyungMann Kim and others published Group Sequential Methods with Applications to Clinical Trials | Find, read and cite all the research Author: Kyungmann Kim.

Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics) Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis.

Medical books Group Sequential Methods with Applications to Clinical Trials. Sequential Methods for Clinical Trials methods” (See Group Sequential Methods in Biomedical Research), a title which unfortunately has led to a false distinction from the wider family of sequential methods of which they are a part.

The mathematical answer to the overshoot problem was developed from renewal theory by Siegmund [47]. Earlier theory Cited by: 1. Synopsis. Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis.

These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings.5/5(1).

Group sequential tests for Phase III clinical trials. The setting for this lecture is a Phase III clinical trial, comparing a new treatment against the current standard.

Two positive Phase III trials are usually required to support the case made to regulators for the approval of a new Size: KB. Group Sequential Clinical Trial Design with the RCTdesign Package, the width of a 95% con dence interval) or that will allow a decision to reject the null hypothesis to be made with high probability (e.g., 80%, 90%, 95%, or % statistical power) when a speci c alternative hypothesis is true.

This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book.

: Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics) () by Jennison, Christopher; Turnbull, Bruce W. and a great selection of similar New, Used and Collectible Books available now at 4/5(3).

This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the : $ Group Sequential Methods with Applications to Clinical Trials | Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis.

These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early.

The advantages of sequential methods for clinical trials were also soon noticed. In the medical context the benefits of stopping early can be ethical as well as purely economic. Bross 11 introduced sequential medical plans for comparing two sets of binary responses, and Kilpatrick & Oldham 32 applied the sequential t ‐test to a comparison of Cited by: 1.

Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation.

Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. Group Sequential Methods with Applications to Clinical Trials. Get this from a library.

Group sequential methods with applications to clinical trials. [Christopher Jennison; Bruce W Turnbull] -- "Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses.

It describes group sequential stopping rules which can. Download group sequential methods with applications to clinical trials or read online books in PDF, EPUB, Tuebl, and Mobi Format. Click Download or Read Online button to get group sequential methods with applications to clinical trials book now.

This site is like a library, Use search box in the widget to get ebook that you want. Group. Group Sequential Methods with Applications to Clinical Trials. The book will open the way for including causal analysis in the standard curriculum of statistics, artifical intelligence.

Single arm trials with normally distributed data. Suppose we conduct a group-sequential single-arm clinical trial of some experimental treatment with up to K analyses of a single sample of normally distributed data with a cumulative total of n k observations at look k,k=1,K.

At each look the data observed up to that point will be analysed and a decision made whether or not to Author: Nigel Stallard, Susan Todd, Elizabeth G. Ryan, Simon Gates. Text Books. There are no required texts for this course but lecture notes will draw heavily from: Jennison, C.

and Turnbull, B. () Group Sequential Methods with Applications to Clinical Trials, Boca Raton: CRC Size: KB.Group Sequential Methods with Applications to Clinical Trials" surveys and extends current methods for planning and conducting interim analyses.

It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. About For Books Group Sequential Methods with Applications to Clinical Trials (Chapman Hall/CRC.

cemew. Follow. 11 months ago PDF Download Group Sequential Methods with Applications to Clinical Trials Chapman HallCRC Download Full Ebook. Choaib15omran.